This study investigates the effect of persistent job-related concerns on psychological distress among Japanese young adults to contribute to a perspective on the relationship between work and mental health. Besides, the study aims to identify which job-related concerns are more likely to affect psychological distress for young adults in Japan. The present study uses wave 8 (2011) and wave 11 (2014) from the Japanese Life Course Panel Survey of High School Graduates to focus on the effect of persistence of stressors on young adults’ mental health. The results confirm that the longer-term exposure to jobrelated concerns increases psychological distress among Japanese young adults. In terms of long-term exposure to job-related concerns, the results also point out that persistent concerns about their interpersonal relationships at the workplace impact higher levels of psychological distress among the three types of persistent job-related concerns for young adults in Japan.